If a chameleon was the size of a horse, it would be amazing because it could change the colour of it's skin and do all the chameleon things that it does but in a large size. Perhaps at a large size, small lizards are dangerous.
If it was difficult for Chameleons to live in a enlarged form or it was painful for them then perhaps it isn't right to breed them that way. They have a tongue that shoots out like a grappling hook, perhaps it would attack bigger pray if it was much bigger such as birds or humans. If they were dangerous, I imagined a Sci-Fi villain would keep one has a pet to kill his enemies in a very nasty way. Being eaten alive by a giant pet lizard.
I wonder...